Mutt, Softbeep, and “Could not copy message”
Turns out the softbeep hack I was using to work around my PC speakers not beeping was screwing up Mutt. Solution: unset LD_PRELOAD in ~/.bash_login. Mutt loads up fine, and beeps still go through softbeep.

How are you loading softbeep in the first place? I tried your .bash_login solution but I still can’t get mutt new mail beeps AND mutt space bar behavior to both work at the same time.
Through the /etc/X11/Xsession.d scripts. Either just before or just after seahorse.